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June 18, 2015The Anatolian Journal of CardiologyOpen Access

Heart rate variability and heart rate turbulence in patients with polycystic ovary syndrome

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Key result

PCOS shows no association with differences in HRV or HRT parameters versus healthy controls.

  • n=48

Why the study?

Cardiac autonomic dysfunction may develop in patients with polycystic ovary syndrome, but cardiac autonomic functions assessed by both HRV and HRT have not been evaluated in this population.

Does polycystic ovary syndrome alter cardiac autonomic functions as measured by heart rate variability and heart rate turbulence compared to healthy controls?

Population

23 patients with PCOS and 25 healthy female volunteers matched for age and BMI

Comparison

Patients with PCOS vs healthy female controls

Design

Case-control study

Authors

GÖGülay ÖzkeçeciAfyon Kocatepe UniversityBÜBekir Serdar ÜnlüAfyon Kocatepe UniversityHDHüseyin DursunErciyes University

Discussion

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Overview

No difference in HRV/HRT found in young PCOS patients without comorbidities; leaves open later autonomic changes with disease progression or risk factors.

Study Design

Type

Case-Control (n=48)

Structured PICO

Does polycystic ovary syndrome alter cardiac autonomic functions as measured by heart rate variability and heart rate turbulence compared to healthy controls?

P
Population
48 young women (23 with PCOS and 25 healthy matched controls) evaluated for cardiac autonomic functions using 24-hour ambulatory ECG.
E
Exposure
Polycystic ovary syndrome (PCOS) disease state
C
Comparator
Healthy female volunteers matched for age and body mass index (BMI)
O
Outcome
Cardiac autonomic functions assessed by time domain parameters of heart rate variability (HRV) and heart rate turbulence (HRT), including turbulence onset (TO) and turbulence slope, measured via 24-hour ambulatory electrocardiogramsurrogate

Cardiac autonomic functions, as measured by heart rate variability and turbulence, are not significantly altered in young, non-obese women with early-stage polycystic ovary syndrome.

Limitations

  • Patients were in the early stage of the disease with an absence of concomitant cardiovascular risk factors
  • Patients were in the early stage of the disease without concomitant cardiovascular risk factors, which may explain the lack of observed differences.

Cite This Study

Özkeçeci et al. (2015) conducted a case-control in Polycystic ovary syndrome (PCOS) (n=48). Polycystic ovary syndrome (PCOS) vs. Healthy controls was evaluated on Heart rate variability (HRV) and heart rate turbulence (HRT) parameters. Polycystic ovary syndrome was not associated with significant differences in heart rate variability or heart rate turbulence parameters compared to healthy controls.

synapsesocial.com/papers/6aa91be33c4f3f2f14b3f137https://doi.org/10.5152/anatoljcardiol.2015.6307
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Impact of Reduced Heart Rate Variability on Risk for Cardiac Events1996 · 1,768 citations
  2. 2Analysis of heart rate variability in polycystic ovary syndrome2010 · 55 citations
  3. 3Heart Rate Variability in Young Women with Polycystic Ovary Syndrome2006 · 113 citations
  4. 4Polycystic Ovary Syndrome (PCOS): Arguably the Most Common Endocrinopathy Is Associated with Significant Morbidity in Women1999 · 510 citations
  5. 5Prevalence of type 2 diabetes mellitus and impaired glucose tolerance in Asian women with polycystic ovary syndrome2001 · 121 citations