Key result
Polycystic ovary syndrome was not associated with significant differences in heart rate variability or heart rate turbulence parameters compared to healthy controls.
Why the study?
Cardiac autonomic dysfunction may develop in patients with polycystic ovary syndrome, but cardiac autonomic functions assessed by both HRV and HRT have not been evaluated in this population.
Does polycystic ovary syndrome alter cardiac autonomic functions as measured by heart rate variability and heart rate turbulence compared to healthy controls?
Case-Control (n=48)
Does polycystic ovary syndrome alter cardiac autonomic functions as measured by heart rate variability and heart rate turbulence compared to healthy controls?
Answers are grounded in this paper and cite their sources.
Cardiac autonomic functions, as measured by heart rate variability and turbulence, are not significantly altered in young, non-obese women with early-stage polycystic ovary syndrome.
OBJECTIVE: Cardiac autonomic dysfunction may develop in patients with polycystic ovary syndrome (PCOS). Heart rate variability (HRV) and heart rate turbulence (HRT) are used in assessing cardiac autonomic functions. The goal of this study was to compare the cardiac autonomic functions in patients with PCOS and healthy controls. To our knowledge, this is the first study evaluating cardiac autonomic functions in patients with PCOS with respect to both HRV and HRT. METHODS: Twenty-three patients with PCOS (mean age 22.8±3.9 years) and 25 healthy female volunteers who were matched for age and body mass index (BMI) (mean age 23.5±6.2 years) were enrolled in this as case-control study. Twenty-four hour ambulatory electrocardiogram recordings of all participants were taken using Pathfinder software. The time domain parameters of HRV and HRT, including turbulence onset (TO) and turbulence slope, were calculated. Diagnosis of PCOS was made with physical and laboratory findings of hirsutism or biochemical hyperandrogenism and chronic anovulation. Diabetes mellitus, other hormon disorders or hormon therapy, pregnancy, atrial fibrilation, obesite, chronic diseases, disorders of the autonomic nervous system, a history of drug use affecting the autonomic nervous system were excluded. RESULTS: There were no significant differences in HRV and HRT parameters between the two groups. Cardiovascular risk factors, such as BMI, blood pressure, fasting blood glucose, and lipid parameters, were also similar. Triangular index measure of HRV was negatively correlated with high density lipoprotein cholesterol levels (r=-0.47, p<0.05), while age and BMI were significantly correlated with TO (r=0.31 and 0.47, respectively; p<0.05 for all). CONCLUSION: Cardiac autonomic functions were not found to be altered in patients with PCOS in comparison with healthy controls. These results may be explained with the absence of concomitant cardiovascular risk factors with the patients being in the early stage of the disease.
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Özkeçeci et al. (2015) conducted a case-control in Polycystic ovary syndrome (PCOS) (n=48). Polycystic ovary syndrome (PCOS) vs. Healthy controls was evaluated on Heart rate variability (HRV) and heart rate turbulence (HRT) parameters. Polycystic ovary syndrome was not associated with significant differences in heart rate variability or heart rate turbulence parameters compared to healthy controls.
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