Key result
Electrical stimulation at 2 Hz or greater combined with beta-adrenergic activation raised intramitochondrial free calcium to >500 nmol/L, a level associated with significant dehydrogenase activation.
Population
Single, isolated rat cardiac myocytes
Comparison
Electrical stimulation, isoprenaline, partial… vs Quiescent cells or baseline conditions
Design
Preclinical
Authors
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Technique enables [Ca2+]m quantification in myocytes; leaves open its role in mitochondrial regulation.
In isolated rat cardiac myocytes, electrical stimulation combined with beta-adrenergic activation increases intramitochondrial free calcium to levels that activate pyruvate dehydrogenase.
Lisa et al. (1993) studied this question. Electrical stimulation and isoprenaline vs. Quiescent cells was evaluated on Intramitochondrial free Ca2+ ([Ca2+]m). Electrical stimulation at 2 Hz or greater combined with beta-adrenergic activation raised intramitochondrial free calcium to >500 nmol/L, a level associated with significant dehydrogenase activation.
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