Key result
End-systolic indexes measured by echocardiography changed significantly with dobutamine and hypothyroidism (P < 0.05), appearing more sensitive to inotropic state than ejection phase indexes.
Why the study?
Are end-systolic relationships measured by echocardiography and simultaneous LV pressure more sensitive to inotropic state than ejection phase indexes in mice?
Population
13 intact mice
Comparison
Measurement of end-systolic relationships using… vs Ejection phase indexes
Design
Preclinical
Authors
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End-systolic indexes may aid contractility assessment in murine models; hypothesis-generating for human echocardiography.
Are end-systolic relationships measured by echocardiography and simultaneous LV pressure more sensitive to inotropic state than ejection phase indexes in mice?
p-value: p=< 0.05
End-systolic indexes can be accurately measured in intact mice by echocardiography with simultaneous LV pressure recording and are more sensitive to inotropic state than ejection phase indexes.
Williams et al. (1998) studied this question. Altered contractility (dobutamine and hypothyroidism) was evaluated on Change in end-systolic relationships (ESPDR and ESSVR gamma-intercepts) (p=< 0.05). End-systolic indexes measured by echocardiography changed significantly with dobutamine and hypothyroidism (P < 0.05), appearing more sensitive to inotropic state than ejection phase indexes.
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