Key result
Insulin resistance (HOMA-IR > 2.5) was significantly associated with a higher coronary artery remodeling index (1.074 vs 1.042, p=0.013) compared to patients without insulin resistance.
Why the study?
Is insulin resistance associated with positive coronary artery remodeling in patients undergoing PCI?
Population
298 consecutive patients who received percutaneous coronary intervention under IVUS guidance for de novo…
Comparison
Insulin resistance positive (HOMA-IR > 2.5) vs Insulin resistance negative (HOMA-IR ≤ 2.5)
Design
Cross-sectional, Two expert operators blinded to the clinical presentation…
Authors
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IR by HOMA-IR was associated with positive remodeling; hypothesis-generating for prospective studies before clinical use.
Cross-Sectional (n=298)
No
Is insulin resistance associated with positive coronary artery remodeling in patients undergoing PCI?
Absolute Event Rate: 1.074% vs 1.042%
p-value: p=0.013
Increased insulin resistance is independently associated with a higher remodeling index and positive coronary artery remodeling, suggesting a mechanism for increased plaque vulnerability.
Kim et al. (2015) conducted a cross-sectional in Coronary artery disease (n=298). Insulin resistance (HOMA-IR > 2.5) vs. No insulin resistance (HOMA-IR ≤ 2.5) was evaluated on Coronary artery remodeling index (p=0.013). Insulin resistance (HOMA-IR > 2.5) was significantly associated with a higher coronary artery remodeling index (1.074 vs 1.042, p=0.013) compared to patients without insulin resistance.
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