Key result
Human platelets possess specific binding sites for HDL (max 1,585 particles) and LDL (max 7,075 particles), with HDL effectively inhibiting LDL binding.
Population
Washed human platelets and human plasma low density lipoproteins (LDL) and high density lipoproteins (HDL)
Design
Preclinical
Authors
Loading...
Lipoprotein-platelet interactions at body temperature may modulate thrombosis risk; leaves open in vivo relevance and clinical translation.
Demonstrates specific, distinct binding sites for HDL and LDL on human platelets, with HDL capable of inhibiting LDL binding.
Curtiss et al. (1984) studied this question. Low density lipoproteins (LDL) and high density lipoproteins (HDL) was evaluated on Lipoprotein binding to platelets. Human platelets possess specific binding sites for HDL (max 1,585 particles) and LDL (max 7,075 particles), with HDL effectively inhibiting LDL binding.
Synapse has enriched 3 closely related papers on similar clinical questions. Consider them for comparative context: