August 1, 1984Blood

Interaction of plasma lipoproteins with human platelets

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Population

Washed human platelets and human plasma low density lipoproteins (LDL) and high density lipoproteins (HDL)

Design

Preclinical

Authors

Discussion

Distinct platelet HDL/LDL binding sites may affect thrombosis risk; animal data leave human relevance and clinical impact open.

Population

Washed human platelets and human plasma low density lipoproteins (LDL) and high density lipoproteins (HDL)

Intervention

Radioiodination of LDL and HDL and incubation at 37, 22, or 4 degrees C

Outcome

Binding characteristics (affinity, saturation, dissociation constant, number of binding sites) of LDL and HDL to plateletssurrogate

Human platelets possess two types of lipoprotein interaction sites: an HDL binding site and an LDL binding site that recognizes or is altered by HDL.

Curtiss et al. (1984) studied this question.

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