July 1, 1989Journal of Biological ChemistryOpen Access

Purification and Identification of the Lipoprotein-binding Proteins from Human Blood Platelet Membrane

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Population

Human blood platelet membranes and intact platelets

Design

Preclinical

Authors

EKElisabeth KollerHanusch Hospital FKFranz KollerUniversity of Vienna BBBernd R. BinderInfineon Technologies (Germany)

Discussion

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Implication

May link lipoproteins to platelet activation via GP IIb-IIIa; leaves open in vivo relevance for thrombosis.

Structured PICO

Population

Human blood platelet membranes and intact platelets

Intervention

Lipoproteins (HDL, LDL), antibodies against GPIIb and GPIIIa, and fibrinogen

Outcome

Identification of lipoprotein-binding membrane glycoproteins and characterization of their binding interactionssurrogate

This study identifies the glycoprotein IIb-IIIa complex as the specific binding site for plasma lipoproteins on human platelets, providing mechanistic insight into platelet-lipoprotein interactions.

Cite This Study

Koller et al. (1989) studied this question.

synapsesocial.com/papers/6a8294985bcab2ccdb8d5f3c https://doi.org/10.1016/s0021-9258(18)63874-8

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Purification and Identification of the Lipoprotein-binding Proteins from Human Blood Platelet Membrane

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Purification and Identification of the Lipoprotein-binding Proteins from Human Blood Platelet Membrane

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider