January 1, 1990Platelets

Detection of a Protein in Human Platelet Membranes which Binds Low-density Lipoproteins

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Population

Human blood platelets, including those from patients with homozygous familial hypercholesterolaemia

Design

Preclinical

Authors

DHDavid G. HassallUniversity of London KDKalpna DesaiTranslational Research in Oncology JOJames S. OwenThe Royal Free Hospital

Discussion

Member takes

Implication

May inform platelet-LDL interactions in research; leaves open any clinical role in thrombosis or dyslipidemia.

Structured PICO

Population

Human blood platelets, including those from patients with homozygous familial hypercholesterolaemia

Intervention

Incubation with radio-iodinated low-density lipoproteins (LDL)

Outcome

Characterization of LDL binding sites on platelet membranessurrogate

Demonstrates that human platelets possess a specific, high-affinity LDL binding protein distinct from the classical LDL receptor, which may mediate LDL-induced platelet reactivity.

Cite This Study

Hassall et al. (1990) studied this question.

synapsesocial.com/papers/6a8294985bcab2ccdb8d5f3a https://doi.org/10.3109/09537109009009193

View Full Paper

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Detection of a Protein in Human Platelet Membranes which Binds Low-density Lipoproteins

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Detection of a Protein in Human Platelet Membranes which Binds Low-density Lipoproteins

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider