February 1, 1999Arteriosclerosis Thrombosis and Vascular Biology

Low-Density Lipoprotein Enhances Platelet Secretion Via Integrin-α IIb β 3 –Mediated Signaling

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Why the study?

Does LDL enhance platelet secretion via integrin-alphaIIbbeta3-mediated signaling in human platelets?

Population

Human platelets

Comparison

Preincubation with low-density lipoprotein at… vs Platelets without LDL preincubation or in the…

Design

Preclinical

Authors

CHChristian M. HackengSt. Antonius Ziekenhuis MHMerei HuigslootUniversity College Cork MPMarc W. PladetUtrecht University

Discussion

Member takes

Implication

May link hypercholesterolemia to platelet hyperreactivity via alphaIIbbeta3; hypothesis-generating in animal models, human studies required.

Structured PICO

Does LDL enhance platelet secretion via integrin-alphaIIbbeta3-mediated signaling in human platelets?

Population

Human platelets (including normal, alphaIIbbeta3-deficient, fibrinogen-deficient, and von Willebrand Factor-deficient platelets)

Intervention

Preincubation with low-density lipoprotein (LDL) at concentrations up to 2 g/L

Comparator

Platelets without LDL preincubation or in the presence of specific inhibitors (e.g., PAC1, anti-alphaIIb, GRGDS, HHLGGAKQAGDV, bisindolylmaleimide, herbimycin A)

Outcome

Platelet secretion (measured by 14C-serotonin release) and fibrinogen surface expressionsurrogate

High concentrations of LDL sensitize platelets to stimulation via ligand-induced outside-in signaling through integrin-alphaIIbbeta3, providing a mechanistic link between hypercholesterolemia and platelet hyperreactivity.

Cite This Study

Hackeng et al. (1999) studied this question.

synapsesocial.com/papers/6a7078e2f44fa9f079de1f98 https://doi.org/10.1161/01.atv.19.2.239

View Full Paper

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Implication

May link hypercholesterolemia to platelet hyperreactivity via alphaIIbbeta3; hypothesis-generating in animal models, human studies required.

Low-Density Lipoprotein Enhances Platelet Secretion Via Integrin-α IIb β 3 –Mediated Signaling

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Low-Density Lipoprotein Enhances Platelet Secretion Via Integrin-α IIb β 3 –Mediated Signaling

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider