Key result
In rat carotid body chemoreceptor cells, an inwardly rectifying chloride current is activated by extracellular acidosis and inhibited by alkalosis in the pH range of 7.0-7.8.
Population
Isolated chemoreceptor cells of the rat carotid body
Design
Preclinical
Authors
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May link pHo to carotid body Cl currents in vitro; leaves open in vivo role in acid-base cardiorespiratory responses.
Rat carotid body chemoreceptor cells express an inwardly rectifying chloride current directly regulated by extracellular pH, which may participate in intracellular acidification and membrane depolarization during acidic challenge.
Petheö et al. (2001) studied this question. Extracellular acidosis vs. Extracellular alkalosis was evaluated on Chloride current activation. In rat carotid body chemoreceptor cells, an inwardly rectifying chloride current is activated by extracellular acidosis and inhibited by alkalosis in the pH range of 7.0-7.8.
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