Key result
CrossFit training for 12 weeks increased the relative expression of the ACTN3 gene by 2.3 times (p=0.035) and the ACE gene by 3.0 times (p=0.049).
Why the study?
To analyze the effects of 12 weeks of training on ACTN3 and ACE gene expression in CrossFit athletes.
Does 12 weeks of CrossFit training alter ACTN3 and ACE gene expression in CrossFit athletes?
Observational (n=18)
Does 12 weeks of CrossFit training alter ACTN3 and ACE gene expression in CrossFit athletes?
CrossFit training for 12 weeks induces overexpression of ACTN3 and ACE genes, which correlates with power performance.
Answers are grounded in this paper and cite their sources.
CrossFit training may alter ACTN3/ACE expression in small athlete cohort; leaves open genotype-specific adaptation in prospective trials.
Background: CrossFit is known as a functional fitness training high-intensity exercise to improve physical performance. The most studied polymorphisms are the ACTN3 R577X gene, known for speed, power, and strength, and ACE I/D, related to endurance and strength. The present investigation analyzed the effects of training on ACTN3 and ACE gene expression in CrossFit athletes for 12 weeks. Methods: the studies included 18 athletes from the Rx category, where ACTN3 (RR, RX, XX) and ACE (II, ID, DD) characterization of genotypes and tests of maximum strength (NSCA), power (T-Force), and aerobic endurance (Course Navette) were performed. The technique used was the reverse transcription-quantitative PCR real-time polymerase chain reaction (RT-qPCR) for the relative expression analysis. Results: the relative quantification (RQ) values for the ACTN3 gene increased their levels 2.3 times (p = 0.035), and for ACE, they increased 3.0 times (p = 0.049). Conclusions: there is an overexpression of the ACTN3 and ACE genes due to the effect of training for 12 weeks. Additionally, the correlation of the expression of the ACTN3 (p = 0.040) and ACE (p = 0.030) genes with power was verified.
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Peña-Vázquez et al. (2023) conducted an observational in CrossFit athletes (n=18). CrossFit training was evaluated on Relative expression of ACTN3 and ACE genes (2.3-fold increase for ACTN3; 3.0-fold increase for ACE, p=0.035 for ACTN3; 0.049 for ACE). CrossFit training for 12 weeks increased the relative expression of the ACTN3 gene by 2.3 times (p=0.035) and the ACE gene by 3.0 times (p=0.049).
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