Key result
Implantation of a novel autologous tissue-engineered heart valve (Biovalve) in 20 adult goats was feasible, showing smooth leaflet movement and characteristic tissue construction up to 3 years 4 months.
Why the study?
To test the feasibility and long-term availability of a novel autologous conduit-type tissue-engineered heart valve without foreign bodies in large animal experiments.
Does a novel autologous tissue-engineered heart valve demonstrate feasibility and long-term function in a large animal model?
Does a novel autologous tissue-engineered heart valve demonstrate feasibility and long-term function in a large animal model?
A novel autologous tissue-engineered heart valve without foreign bodies demonstrated long-term feasibility, function, and biocompatibility in a large animal model.
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Supports preclinical feasibility of autologous Biovalves; leaves open human translation and durability testing.
Takewa et al. (2019) studied Heart valve replacement (animal model) (n=20). Autologous tissue-engineered heart valve (Biovalve) was evaluated on Feasibility and long-term availability. Implantation of a novel autologous tissue-engineered heart valve (Biovalve) in 20 adult goats was feasible, showing smooth leaflet movement and characteristic tissue construction up to 3 years 4 months.
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