Key result
Implantation of a novel autologous tissue-engineered heart valve in 21 goats was feasible, showing smooth leaflet movement and maximum durability up to 3 years 7 months without anticoagulants.
Why the study?
To test the feasibility and long-term availability of a novel autologous conduit-type tissue-engineered heart valve developed without foreign materials in large animal experiments.
Does a novel autologous tissue-engineered heart valve demonstrate feasibility and long-term availability in an adult goat model?
Does a novel autologous tissue-engineered heart valve demonstrate feasibility and long-term availability in an adult goat model?
A novel autologous tissue-engineered heart valve demonstrated long-term feasibility and biocompatibility up to 3.5 years in a goat model, suggesting potential as a viable bioprosthesis.
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Feasibility of autologous Biovalve shown in large animals; leaves open human translation and durability.
Takewa et al. (2019) studied Heart valve replacement (n=21). Autologous tissue-engineered heart valve (Biovalve) was evaluated on Feasibility and long-term availability. Implantation of a novel autologous tissue-engineered heart valve in 21 goats was feasible, showing smooth leaflet movement and maximum durability up to 3 years 7 months without anticoagulants.
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