Why the study?
Does an in-body tissue-engineered aortic valve based on 3D printer molding function effectively in a goat model?
Population
Goat model (N=3) for in vivo implantation and in vitro pulsatile circulation circuit for testing 30 molds
Design
Preclinical
Follow-up
1 month (in vivo), 10 days (in vitro)
Authors
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Feasibility in goats warrants expanded preclinical evaluation; leaves open clinical translation of in-body tissue-engineered valves.
Does an in-body tissue-engineered aortic valve based on 3D printer molding function effectively in a goat model?
In-body tissue-engineered autologous heart valves created using 3D-printed molds demonstrate functional feasibility and short-term durability in a preclinical goat model.
Nakayama et al. (2014) studied this question.
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