Key result
The subcutaneous lead array adjunct to the transvenous ICD lead significantly reduced mean monophasic defibrillation thresholds from 23.3 to 13.5 joules (P<0.001) compared to lead-alone.
Why the study?
Does a subcutaneous lead array adjunct lower defibrillation thresholds compared to a transvenous lead alone in patients undergoing ICD implantation?
Population
20 patients undergoing ICD implantation, mean age 63.7 +/- 2.5 years, mean ejection fraction 0.34 +/- 0.04.
Comparison
Subcutaneous lead array adjunct to transvenous… vs Transvenous lead-alone, using the proximal coil…
Design
RCT, Randomized to receive the SQ Array through the CPI Ventak PRx/Endotak 70…
Follow-up
Intraoperative
Authors
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May lower thresholds in select patients; observational data leave open randomized confirmation before practice change.
RCT (n=20)
randomized
Does a subcutaneous lead array adjunct lower defibrillation thresholds compared to a transvenous lead alone in patients undergoing ICD implantation?
Mean Difference: -9.8
Absolute Event Rate: 13.5% vs 23.3%
p-value: p=< 0.001
Higgins et al. (1995) conducted an RCT in Implantable cardioverter defibrillator (ICD) implantation (n=20). Subcutaneous lead array (SQ Array) adjunct vs. Transvenous lead-alone was evaluated on Mean monophasic defibrillation threshold (DFT) (MD -9.8 joules, p=< 0.001). The subcutaneous lead array adjunct to the transvenous ICD lead significantly reduced mean monophasic defibrillation thresholds from 23.3 to 13.5 joules (P<0.001) compared to lead-alone.
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