Key result
In experimental murine coxsackievirus B3 myocarditis, cardiomyocyte apoptosis peaked on day 5 and correlated with a rapid decline in plasma glutathione (r = -0.52, P = 0.003).
Effect estimate: r = -0.52
p-value: p=0.003
In a murine model of viral myocarditis, decreased plasma glutathione levels and altered Bax/Bcl-X(L) expression identify the phase of peak cardiomyocyte apoptosis.
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Apoptosis indicators in murine CVB3 myocarditis may guide future work; leaves open human translation.
Kytö et al. (2004) studied Viral myocarditis. Coxsackievirus B3 infection was evaluated on Cardiomyocyte apoptosis and plasma glutathione levels (r = -0.52, p=0.003). In experimental murine coxsackievirus B3 myocarditis, cardiomyocyte apoptosis peaked on day 5 and correlated with a rapid decline in plasma glutathione (r = -0.52, P = 0.003).
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