Key result
ATP hydrolysis induces an allosteric conformational change in the neck region of intact myosin, rendering nonessential thiol 3 groups the most reactive.
Population
Intact myosin molecules
Design
Preclinical
Authors
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Does not inform clinical myosin modulation; extends biochemical models of sarcomere dynamics for research.
The hydrolytic step of ATP induces an allosteric conformational change in the neck region of intact myosin, evidenced by increased reactivity of nonessential thiol 3 groups.
Schaub et al. (1978) studied this question. ATP hydrolysis was evaluated on Allosteric conformational change in the neck region of intact myosin. ATP hydrolysis induces an allosteric conformational change in the neck region of intact myosin, rendering nonessential thiol 3 groups the most reactive.
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