January 1, 1979The Journal of Biochemistry

The Sulfhydryl Groups Involved in the Active Site of Myosin B Adenosinetriphosphatase

View Full Paper

Ask AI

Bookmark

Population

Myosin B, light meromyosin (LMM), and myosin rods (basic science model)

Design

Preclinical

Authors

THTsuneyoshi HorigomeNiigata University TYTatsuhisa YamashitaYamamoto Hospital

Discussion

Member takes

Implication

Does not inform clinical myosin targeting; leaves open inter-molecular interactions in cardiac thick filaments.

Structured PICO

Population

Myosin B, light meromyosin (LMM), and myosin rods (basic science model)

Intervention

Chemical cleavage at the amino peptide bonds of cysteine residues following modification with N-ethylmaleimide (NEM) or 5,5′-dithiobis-(2-nitrobenzoic acid) (DTNB)

Outcome

Location of the specific sulfhydryl group (Sa) in the rod portion

The specific sulfhydryl group (Sa) involved in the active site of myosin B ATPase is situated approximately 790 Å from the carboxyl terminus of the rod, suggesting it could interact with a head of the adjacent myosin molecule in the thick filament.

Cite This Study

Horigome et al. (1979) studied this question.

synapsesocial.com/papers/6a8d017ee3b89f2bdacc9835 https://doi.org/10.1093/oxfordjournals.jbchem.a132315

View Full Paper

Ask AI

Bookmark

The Sulfhydryl Groups Involved in the Active Site of Myosin B Adenosinetriphosphatase

Discussion

Member takes

Implication

Structured PICO

Cite This Study

The Sulfhydryl Groups Involved in the Active Site of Myosin B Adenosinetriphosphatase

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider