Key result
In dog atrial myocytes, choline chloride activated a background conductance comparable to ACh-dependent K+ current and a time-dependent K+ current similar to IK.
Choline chloride activates specific time-dependent and time-independent potassium currents in dog atrial myocytes, which has implications for electrophysiological studies using choline as a sodium substitute.
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No immediate clinical implications; leaves open relevance of choline substitution to human atrial electrophysiology.
Fermini et al. (1994) studied this question. Choline chloride vs. Sodium chloride was evaluated on Activation of time-dependent and time-independent K+ currents. In dog atrial myocytes, choline chloride activated a background conductance comparable to ACh-dependent K+ current and a time-dependent K+ current similar to IK.
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