Key result
Oral amiodarone demonstrated a mean absolute bioavailability of 65% ± 22% compared to intravenous injection, with bioequivalence across different oral formulations.
Why the study?
What is the absolute and relative bioavailability of different oral forms of amiodarone compared to intravenous administration in normal subjects?
Population
12 normal subjects
Comparison
Amiodarone 400 mg oral vs Amiodarone 5 mg/kg intravenous (IV)
Design
Other
Authors
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May permit substitution among oral amiodarone products; leaves open efficacy equivalence in clinical practice.
What is the absolute and relative bioavailability of different oral forms of amiodarone compared to intravenous administration in normal subjects?
Oral amiodarone has a mean absolute bioavailability of 65%, with incomplete absorption likely due to a first-pass effect rather than formulation dissolution characteristics.
Pourbaix et al. (1985) studied Healthy subjects (n=12). Oral amiodarone vs. Intravenous amiodarone (5 mg/kg) was evaluated on Absolute bioavailability. Oral amiodarone demonstrated a mean absolute bioavailability of 65% ± 22% compared to intravenous injection, with bioequivalence across different oral formulations.
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