Key result
Fever and hyponatremia associated with SARS-CoV-2 infection unmasked a type 1 Brugada pattern electrocardiogram, which normalized upon resolution of the fever and electrolyte abnormalities.
Case Report (n=1)
Fever and severe hyponatremia in the setting of COVID-19 can unmask a type 1 Brugada ECG pattern, which may resolve upon correction of these triggers.
May indicate COVID-19 unmasking Brugada; hypothesis-generating and does not support practice change.
Brugada syndrome is an autosomal dominant genetic disorder that primarily affects myocardial sodium channels and has been associated with an increased risk of ventricular tachyarrhythmias and sudden cardiac death. Here, we report a case of a 58-year-old Hispanic male with a history significant for prior pulmonary tuberculosis infection who presented with pleuritic left-sided chest pain associated with body aches, productive cough, fevers, and chills and was found to be positive for SARS-CoV-2 by real-time reverse-transcription-polymerase chain reaction (rRT-PCR). Electrocardiogram (ECG, EKG) on presentation demonstrated a coved ST-segment elevation in V1-V2, suggesting Brugada pattern type 1 without evidence of ischemic changes. EKG changes normalized once fever and hyponatremia improved.
No takes yet. Share an insight, caveat, or question.
Ayad et al. (2021) conducted a case report in Brugada pattern unmasked by fever and hyponatremia in SARS-CoV-2 infection (n=1). Fever and hyponatremia (associated with COVID-19) was evaluated on Brugada pattern ECG unmasking. Fever and hyponatremia associated with SARS-CoV-2 infection unmasked a type 1 Brugada pattern electrocardiogram, which normalized upon resolution of the fever and electrolyte abnormalities.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: