Key result
The AGT M235T gene polymorphism was associated with essential hypertension in a high-altitude Han population, whereas β2-AR Arg16Gly and CYP11B2 C-344T polymorphisms were not.
Why the study?
Are AGT M235T, β2-AR Arg16Gly, and CYP11B2 C-344T gene polymorphisms associated with essential hypertension in a high-altitude Han population?
Case-Control (n=814)
Are AGT M235T, β2-AR Arg16Gly, and CYP11B2 C-344T gene polymorphisms associated with essential hypertension in a high-altitude Han population?
p-value: p=0.05
The AGT M235T polymorphism, but not β2-AR Arg16Gly or CYP11B2 C-344T, is associated with essential hypertension in the Han population living at high altitude in China.
May support genetic risk stratification for EH in high-altitude Han; leaves open replication and functional validation.
We explored the association of angiotensinogen (AGT) M235T, β2 adrenergic receptor (β2-AR) Arg16Gly and aldosterone synthase (CYP11B2) C-344T genes polymorphisms with essential hypertension (EH) in Han population living at high altitude in China. A total of 390 hypertensive subjects (males, 207; females, 183) and 424 normal healthy individuals (males, 251; females, 173) were enrolled in this study based on the inclusion and exclusion criteria. The polymorphisms of AGT M235T, β2-AR Arg16Gly, CYP11B2 C-344T genes were analyzed by Snapshot mini sequencing method. The frequencies of CC genotype and C allele of AGT M235T in EH group were higher than in control (p 0.05, respectively), in gender-specific analysis, the differences were also not found (p>0.05, respectively). This finding suggests that the polymorphism of AGT M235T was correlated with EH in Han population living at high altitude in China, however, β2-AR Arg16Gly and CYP11B2 C-344T polymorphism were unlikely to associated with hypertensive subjects of this population.
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Li et al. (2016) conducted a case-control in Essential hypertension (n=814). AGT M235T, β2-AR Arg16Gly, and CYP11B2 C-344T gene polymorphisms vs. Normal healthy individuals (no essential hypertension) was evaluated on Essential hypertension (p=0.05). The AGT M235T gene polymorphism was associated with essential hypertension in a high-altitude Han population, whereas β2-AR Arg16Gly and CYP11B2 C-344T polymorphisms were not.
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