Key result
Double premature stimulation (S3) was associated with significantly greater temporo-spatial dispersion of repolarization compared to single premature stimulation (S2) in the intact ventricle.
Why the study?
Does double premature stimulation (S3) increase temporo-spatial dispersion of repolarization compared to single premature stimulation (S2) in the intact ventricle?
Population
Five closed-chest anesthetized dogs
Comparison
Double premature stimulation (S3) vs Single premature stimulation (S2)
Design
Preclinical
Authors
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May increase proarrhythmic risk during aggressive stimulation; leaves open translation of canine dispersion findings to human electrophysiology.
Does double premature stimulation (S3) increase temporo-spatial dispersion of repolarization compared to single premature stimulation (S2) in the intact ventricle?
Double premature stimulation (S3) increases temporo-spatial dispersion of repolarization compared to single premature stimulation (S2), which may have implications for understanding arrhythmogenesis.
Kobayashi et al. (1992) studied this question. Double premature stimulation (S3) vs. Single premature stimulation (S2) was evaluated on Temporo-spatial dispersion of repolarization (MAPD). Double premature stimulation (S3) was associated with significantly greater temporo-spatial dispersion of repolarization compared to single premature stimulation (S2) in the intact ventricle.
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