Key result
Metabolic syndrome was associated with a higher prevalence of a non-dipper blood pressure profile (52.0% vs 39.5%, p<0.001), though bedtime medication ingestion mitigated this risk.
Why the study?
Does bedtime administration of antihypertensive medication and the presence of metabolic syndrome affect the prevalence of a non-dipping blood pressure profile in non-diabetic hypertensive patients?
Population
3352 non-diabetic hypertensive subjects (1576 men/1776 women), mean age 53.7 ± 13.1 years.
Comparison
Ingesting at least one blood pressure medication… vs Ingesting all blood pressure medications upon…
Design
Cross-sectional
Follow-up
48 hours
Authors
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MS may mark higher non-dipping risk in treated hypertensives; leaves open whether chronotherapy alters this profile.
Cross-Sectional (n=3,352)
Does bedtime administration of antihypertensive medication and the presence of metabolic syndrome affect the prevalence of a non-dipping blood pressure profile in non-diabetic hypertensive patients?
Absolute Event Rate: 52% vs 39.5%
p-value: p=<.001
Hermida et al. (2011) conducted a cross-sectional in Essential hypertension (n=3,352). Metabolic syndrome vs. No metabolic syndrome was evaluated on Non-dipper blood pressure profile (p=<.001). Metabolic syndrome was associated with a higher prevalence of a non-dipper blood pressure profile (52.0% vs 39.5%, p<0.001), though bedtime medication ingestion mitigated this risk.
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