Why the study?
Do platelets inhibit the lysis of pulmonary microemboli, and can antiplatelet agents facilitate their dissolution in rodent models?
Population
Rodent models (rats and mice) with (125)I-labeled fibrin(ogen) pulmonary microemboli or thrombi
Comparison
Antiplatelet glycoprotein IIb/IIIa antibody 7E3… vs Microemboli formed from fibrin alone, or no…
Design
Preclinical
Follow-up
up to 5 hours
Key result
Platelets suppress pulmonary fibrinolysis, and administration of an antiplatelet glycoprotein IIb/IIIa antibody facilitated the spontaneous dissolution of pulmonary microemboli in rodents.
Authors
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Should not alter pulmonary embolism care; leaves open glycoprotein IIb/IIIa inhibition as a fibrinolysis target.
Do platelets inhibit the lysis of pulmonary microemboli, and can antiplatelet agents facilitate their dissolution in rodent models?
Platelets suppress pulmonary fibrinolysis, and antiplatelet agents like glycoprotein IIb/IIIa inhibitors can facilitate the dissolution of pulmonary microemboli in rodent models.
Murciano et al. (2002) studied Pulmonary microemboli. Antiplatelet glycoprotein IIb/IIIa antibody 7E3 F(ab')2 vs. Control / spontaneous dissolution was evaluated on Dissolution of pulmonary microemboli. Platelets suppress pulmonary fibrinolysis, and administration of an antiplatelet glycoprotein IIb/IIIa antibody facilitated the spontaneous dissolution of pulmonary microemboli in rodents.