Key result
A hospital-wide protocol for emergency PCI increased the proportion of patients achieving door-to-balloon times ≤90 minutes from 28% to 85% compared to historical controls (P < 0.0001).
Why the study?
Does a hospital-wide protocol for catheterization lab activation and immediate transfer reduce door-to-balloon time in patients undergoing emergency PCI?
Cohort (n=526)
No
Does a hospital-wide protocol for catheterization lab activation and immediate transfer reduce door-to-balloon time in patients undergoing emergency PCI?
Absolute Event Rate: 85% vs 28%
p-value: p=< 0.0001
Implementing a hospital-wide protocol for emergency catheterization activation and transfer significantly improves door-to-balloon times and is associated with reduced infarct size and 30-day mortality.
Supports hospital-wide PCI protocols to improve door-to-balloon compliance; leaves open randomized confirmation of clinical outcomes.
OBJECTIVES: This study's aim was to describe a hospital-wide system to deliver rapid door-to-balloon time across the entire spectrum of emergency percutaneous intervention. BACKGROUND: Many patients needing emergency PCI are excluded from door-to-balloon public reporting metric; these groups do not achieve door-to-balloon times ≤90 min and have increased mortality rates. METHODS: We prospectively implemented a protocol for patients with STEMI or other emergency indication for catheterization mandating (1) emergency department physician or cardiologist activation of the catheterization lab and (2) immediate patient transfer to an immediately available catheterization lab by an in-house nursing transfer team. RESULTS: From September 1, 2005 to December 31, 2008, 526 consecutive patients underwent emergency PCI. Median door-to-balloon time was 68 min with 85.7% ≤90 min overall. Important subgroups included primary emergency department (62.5 min), cardiorespiratory arrest (71 min), cardiogenic shock (68 min), need for temporary pacemaker or balloon pump (67 min), initial ECG without ST-elevation (66.5 min), transfer from another ED (84 min), in-hospital (70 min), and activation indications other than STEMI (68 min). Patients presenting to primary ED and in transfer were compared to historical controls. Treatment ≤90 min increased (28%-85%, P < 0.0001). Mean infarct size decreased, as did hospital length-of-stay and admission total hospital costs. Acute myocardial infarction all-cause 30-day unadjusted mortality and risk-standardized mortality ratios were substantially lower than national averages. CONCLUSION: A hospital-wide systems approach applied across the entire spectrum of emergency PCI leads to rapid door-to-balloon time, reduced infarct size and hospitals costs, and low myocardial infarction 30-day all-cause mortality.
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Khot et al. (2015) conducted a cohort in STEMI or other emergency indication for catheterization (n=526). Hospital-wide protocol for rapid door-to-balloon time vs. Historical controls was evaluated on Door-to-balloon time ≤90 min (p=< 0.0001). A hospital-wide protocol for emergency PCI increased the proportion of patients achieving door-to-balloon times ≤90 minutes from 28% to 85% compared to historical controls (P < 0.0001).
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