September 1, 1994Cardiovascular Research

Acidosis and arrhythmias in cardiac muscle

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Why the study?

Does acidosis contribute to arrhythmogenesis in cardiac muscle during myocardial ischaemia?

Population

Cardiac muscle during myocardial ischaemia

Design

Review

Authors

COC. H OrchardIndiana University of Pennsylvania HCHoracio E. CingolaniCentro de Investigaciones Cardiovasculares

Discussion

Member takes

Implication

May guide acid-base management in ischaemia; hypothesis-generating for targeted interventions pending trials.

Structured PICO

Does acidosis contribute to arrhythmogenesis in cardiac muscle during myocardial ischaemia?

Population

Cardiac muscle during myocardial ischaemia

Intervention

Acidosis (changes of pH)

Outcome

Arrhythmogenic consequences (early afterdepolarisations, triggered activity, delayed afterdepolarisations, pulsus alternans, and reentry)

This review highlights the mechanisms by which acidosis during myocardial ischemia contributes to arrhythmogenesis, including afterdepolarisations and reentry.

Cite This Study

Orchard et al. (1994) studied this question.

synapsesocial.com/papers/6a6f3f00e5469ee92be044a2 https://doi.org/10.1093/cvr/28.9.1312

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Bookmark

Acidosis and arrhythmias in cardiac muscle

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Acidosis and arrhythmias in cardiac muscle

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider