Key result
Acidosis produced a marked decrease in heart rate and an increase in P-R interval in the isolated rat heart, with little effect on QRS duration.
Acidosis effects on isolated rat heart rate and PR interval are hypothesis-generating; leaves open translation to human in vivo physiology.
We have investigated the effect of acidosis on the ECG in isolated rat heart to determine whether acidosis has marked effects on the ECG, and have used pharmacological agents to investigate possible mechanisms whereby acidosis alters the ECG. Acidosis produced a marked decrease in heart rate and an increase in P-R interval with little apparent effect on the duration of the QRS complex. The effects of acidosis did not appear to be due to acidosis-induced changes in transmitter release from severed autonomic nerve terminals within the heart. Experimental Physiology (2001) 86.1, 27-31.
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Aberra et al. (2001) studied this question. Acidosis was evaluated on ECG changes (heart rate, P-R interval, QRS duration). Acidosis produced a marked decrease in heart rate and an increase in P-R interval in the isolated rat heart, with little effect on QRS duration.
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