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September 1, 1971Journal of General Virology

Evidence for Large Strands of Ribonucleic Acid Induced by a Bovine Enterovirus

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Population

Bovine enterovirus (serotype VG-5-27) and virus-infected cells

Design

Preclinical

Authors

JCJ. Barklie ClementsInstitute of Virology of the Slovak Academy of SciencesSMStephen J. MartinUniversity of Salford

Discussion

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Implication

Supports cyclic replication in bovine enterovirus; hypothesis-generating and leaves open relevance to human disease.

Structured PICO

P
Population
Bovine enterovirus (serotype VG-5-27) and virus-infected cells
I
Intervention
Fractionation by sedimentation on sucrose gradients, gel filtration through Sepharose 2B, and electrophoresis in acrylamide-agarose gels
O
Outcome
RNA characteristics (molecular weight, single-stranded vs replicative intermediate)surrogate

The identification of single strands of RNA longer than those found in purified virus supports a cyclic model for RNA replication in bovine enterovirus.

Cite This Study

Clements et al. (1971) studied this question.

synapsesocial.com/papers/6a6f5764a528af2d65c2f186https://doi.org/10.1099/0022-1317-12-3-221
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Replication of Poliovirus RNA Studied by Gel Filtration and Electrophoresis1969 · 52 citations
  2. 2A study of the heterogeneous 37s ribonucleic acid induced by foot-and-mouth-disease virus1968 · 10 citations
  3. 3Replication of Foot-and-Mouth Disease Virus Ribonucleic Acid1970 · 13 citations
  4. 4Resolution of Multiple Ribonucleic Acid Species by Polyacrylamide Gel Electrophoresis<sup>*</sup>1967 · 864 citations
  5. 5Molecular Weight of Rhinovirus Ribonucleic Acid1970 · 25 citations