Why the study?
Does the incorporation of IPV into OPV immunization schedules improve systemic and local antibody production in infants?
Does the incorporation of IPV into OPV immunization schedules improve systemic and local antibody production in infants?
Incorporating at least one dose of IPV at the start of the poliovirus immunization schedule tends to increase systemic and local antibody production in infants.
Answers are grounded in this paper and cite their sources.
Mixed IPV-OPV schedules may enhance poliovirus immunogenicity in infants; leaves open optimal sequencing pending controlled trials.
Serum neutralizing, nasopharyngeal neutralizing, and IgA antibodies were determined in 123 infants immunized with one of four schedules containing live oral vaccine (OPV), inactivated vaccine (IPV), or combinations of the two trivalent poliovirus vaccines: OPV-OPV-OPV, IPV-IPV-IPV, IPV-OPV-OPV, or IPV-IPV-OPV. Nearly 100% of individuals formed serum neutralizing antibodies. The highest geometric mean titer (GMT) of antibody to polioviruses 1, 2, and 3 occurred in groups IPV-IPV-OPV, IPV-OPV-OPV, and IPV-IPV-IPV, respectively. Local neutralizing and IgA antibody responses were detected in 41%-88% and 75%-100%, respectively. Peak GMT of nasopharyngeal antibodies differed minimally between immunization groups. The data suggest that incorporation of at least one dose of IPV at the start of the immunization schedule tends to increase systemic as well as local antibody production.
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Faden et al. (1990) studied this question.
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