Key result
Clearance of FMDV from the bovine nasopharyngeal mucosa was associated with significantly higher median counts of CD3+ T cells compared to persistent infection (43 vs 15, p < 0.0001), alongside upregulation of T cell-mediated immunity genes.
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Laser-capture microdissection-microarray profiling identifies nasopharyngeal immunomodulatory signatures in FMDV persistence; leaves open targeted interventions in livestock.
Absolute Event Rate: 43% vs 15%
p-value: p=<0.0001
Stenfeldt et al. (2017) studied Foot-and-mouth disease virus (FMDV) infection (n=16). Clearance of FMDV vs. Persistence of FMDV was evaluated on Median count of CD3+ cells in nasopharyngeal mucosa (p=<0.0001). Clearance of FMDV from the bovine nasopharyngeal mucosa was associated with significantly higher median counts of CD3+ T cells compared to persistent infection (43 vs 15, p < 0.0001), alongside upregulation of T cell-mediated immunity genes.
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