February 1, 1987Hypertension

Microvascular tone in a skeletal muscle of spontaneously hypertensive rats.

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Population

Spontaneously hypertensive rats and normotensive Wistar-Kyoto rats

Comparison

Papaverine treatment vs Normotensive Wistar-Kyoto rats

Design

Preclinical

Authors

GSGeert W. Schmid‐SchönbeinUniversity of California, San Diego BZBenjamin W. ZweifachUniversity of Notre Dame FDF. A. DeLanoUniversity of California, San Diego

Discussion

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Implication

Does not change clinical practice; leaves open whether microvascular tone is a modifiable target in human hypertension.

Structured PICO

Population

Spontaneously hypertensive rats and normotensive Wistar-Kyoto rats

Intervention

Papaverine treatment (to induce vasodilation for tone measurement)

Comparator

Normotensive Wistar-Kyoto rats

Outcome

Microvascular tone in the spinotrapezius muscle microcirculationsurrogate

Elevated microvascular tone contributes to increased vascular resistance in spontaneously hypertensive rats, alongside previously documented anatomical adjustments.

Cite This Study

Schmid‐Schönbein et al. (1987) studied this question.

synapsesocial.com/papers/6a6f9bd85d37378ac1dcab3f https://doi.org/10.1161/01.hyp.9.2.164

Topics

Hypertension management

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Microvascular tone in a skeletal muscle of spontaneously hypertensive rats.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Topics

Microvascular tone in a skeletal muscle of spontaneously hypertensive rats.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Topics

Also Consider