Population
Patients whose paralytic poliomyelitis cases were classified as oral vaccine-associated
Comparison
Oral poliovaccine vs Reference oral vaccine strain
Design
Other
Authors
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May signal OPV reversion risk in humans; leaves open whether changes restore clinical neurovirulence.
Oral poliovaccine viruses can undergo multiple genetic changes during replication in humans, which may contribute to the restoration of neurovirulence.
Kew et al. (1981) studied this question.
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