Why the study?
Do the polyphenols resveratrol and S17834 prevent left ventricular hypertrophy and diastolic dysfunction in mice with diet-induced metabolic heart disease?
Population
Male C57BL/6J mice fed a diet high in fat and sugar (HFHS) to induce metabolic syndrome
Comparison
S17834 or resveratrol administered concurrently… vs Normal diet or HFHS diet without treatment
Design
Preclinical
Follow-up
up to 8 months
Authors
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Preclinical mouse data on S17834 and resveratrol; leaves open translation to human metabolic HFpEF.
Do the polyphenols resveratrol and S17834 prevent left ventricular hypertrophy and diastolic dysfunction in mice with diet-induced metabolic heart disease?
Resveratrol and S17834 prevent the structural and functional sequelae of diet-induced metabolic heart disease in a mouse model.
Qin et al. (2012) studied this question.
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