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April 1, 1990The Journal of PhysiologyOpen Access

Effects of external tetraethylammonium ions and quinine on delayed rectifying K+ channels in mouse pancreatic beta‐cells.

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Population

Mouse pancreatic beta-cells

Design

Preclinical

Authors

KBKrister BokvistSanofi (Germany)PRPatrik RorsmanUppsala UniversityPSPaul A. SmithEnvironment and Climate Change Canada

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Overview

No immediate clinical implications from murine beta-cells; extends mechanistic understanding of delayed rectifier pharmacology.

Structured PICO

P
Population
Mouse pancreatic beta-cells
I
Intervention
External tetraethylammonium ions (TEA+) and quinine
O
Outcome
Mechanisms of block on delayed rectifying K+ channels (whole-cell delayed outward current and single-channel kinetics)surrogate

TEA+ and quinine block delayed rectifying K+ channels in mouse pancreatic beta-cells through distinct mechanisms, with TEA+ reducing current amplitude and quinine decreasing opening duration.

Cite This Study

Bokvist et al. (1990) studied this question.

synapsesocial.com/papers/6a6fbb6331a3df8243280dbahttps://doi.org/10.1113/jphysiol.1990.sp018024
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1The action of external tetraethylammonium ions on unitary delayed rectifier potassium channels of frog skeletal muscle.1987 · 31 citations
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  3. 3Effect of N-bromoacetamide on single sodium channel currents in excised membrane patches.1982 · 213 citations
  4. 4Potassium channels expressed from rat brain cDNA have delayed rectifier properties1988 · 174 citations
  5. 5Down-Regulation of Na<sup>+</sup>/K<sup>+</sup>ATPase Activity by Human Parvovirus B19 Capsid Protein VP12013 · 8,699 citations