Why the study?
Does chronic renal failure alter the anticoagulant half-life of intravenous heparin compared to normal renal function?
Population
Persons with normal renal function and patients in chronic renal failure
Comparison
Intravenous heparin, 0.3 and 0.6 U/ml of blood… vs Normal renal function group
Design
Other
Authors
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May inform heparin dosing adjustments in chronic renal failure; leaves open validation in larger studies.
Does chronic renal failure alter the anticoagulant half-life of intravenous heparin compared to normal renal function?
Heparin half-life is dose-dependent and prolonged in chronic renal failure, which can inform constant infusion dosage schedules.
Perry et al. (1974) studied this question.
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