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June 20, 2003European Journal of Cardio-Thoracic SurgeryOpen Access

Survival estimates at 15 years were 81%, with constant phase mortality less likely after the arterial switch operation and in children with simple TGA.

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Why the study?

What are the long-term survival and functional outcomes of neonates undergoing surgical repair for complete transposition of the great arteries?

Population

829 neonates age less than 15 days with complete transposition of the great arteries, including simple TGA…

Comparison

Surgical repair of TGA vs Comparison between different surgical repair…

Design

Cohort

Follow-up

15 years

Authors

WWWendell H. Williams

Discussion

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Overview

Supports good long-term survival after TGA repair, especially with arterial switch; leaves open prospective studies on functional outcomes.

Structured PICO

What are the long-term survival and functional outcomes of neonates undergoing surgical repair for complete transposition of the great arteries?

P
Population
829 neonates age less than 15 days with complete transposition of the great arteries (TGA), including simple TGA (n=631), TGA with ventricular septal defect (VSD) (n=167), TGA with VSD and pulmonary stenosis (PS) (n=30), or TGA with PS (n=1).
I
Intervention
Surgical repair of TGA (arterial switch [n=516], atrial repair [Senning n=175, Mustard n=110], or Rastelli [n=28])
C
Comparator
Comparison between different surgical repair techniques (arterial switch vs. atrial repair vs. Rastelli)
O
Outcome
Survival at 6 months, 5, 10, and 15 yearshard clinical

Survival 15 years after TGA repair is good (81%), with the arterial switch operation providing the best long-term outcomes, though psychosocial and learning deficits remain prevalent.

Cite This Study

Wendell H. Williams (2003) studied this question.

synapsesocial.com/papers/6a6fec0cc92390ac2d07aec7https://doi.org/10.1016/s1010-7940(03)00264-1
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Surgical outcomes of anatomic repair in congenitally corrected Transposition of the Great Arteries: a 28-Year, Multicentre Dutch experience2026
  2. 2Outcomes of the anatomical repair in patients with congenitally corrected transposition of the great arteries: lessons learned in a high-volume centre†2018 · 21 citations
  3. 3Long‐term growth following neonatal anatomic repair of transposition of the great arteries1993 · 16 citations
  4. 4Long-term results after atrial repair of transposition of the great arteries in early infancy.1982 · 63 citations
  5. 5Natural history and postoperative evaluation of complete transposition of the great arteries.1981 · 4 citations