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January 1, 1977Journal of VirologyOpen Access

Inhibition of host cell protein synthesis by UV-inactivated poliovirus

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Population

Host cells infected with poliovirus

Comparison

UV-irradiated poliovirus and guanidine treatment vs Unirradiated poliovirus or different…

Design

Preclinical

Authors

THT. HelentjarisUniversity of ArizonaEEEllie EhrenfeldNational Institutes of Health

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Implication

Defines minimal poliovirus genome for host shutoff; leaves open extension to other viruses or antiviral strategies.

Structured PICO

P
Population
Host cells infected with poliovirus
I
Intervention
UV-irradiated poliovirus (up to 2,160 ergs/mm2) and guanidine treatment
C
Comparator
Unirradiated poliovirus or different multiplicities of infection
O
Outcome
Inhibition of host cell protein synthesissurrogate

Complete inhibition of host cell protein synthesis can be achieved by a single infectious poliovirus genome per cell, with UV inactivation of this function correlating with loss of infectivity.

Cite This Study

Helentjaris et al. (1977) studied this question.

synapsesocial.com/papers/6a6ff37afebe604dd708c478https://doi.org/10.1128/jvi.21.1.259-267.1977
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Inhibition of Protein Synthesis in Reticulocyte Lysates by Poliovirus1976 · 14 citations
  2. 2Effect of Ultraviolet Light on Mengovirus: Formation of Uracil Dimers, Instability and Degradation of Capsid, and Covalent Linkage of Protein to Viral RNA1974 · 100 citations
  3. 3Temperature-sensitive Poliovirus Mutants Defective in Repression of Host Protein Synthesis are also Defective in Structural Protein1973 · 29 citations
  4. 4Early Inhibition of Cellular DNA Synthesis by High Multiplicities of Infectious and UV-Inactivated Reovirus1973 · 36 citations
  5. 5Mengovirus-Induced Cytopathic Effect in L-Cells: Protective Effect of Interferon1969 · 21 citations