What question did this study set out to answer?

To evaluate the effects of long-term antihypertensive monotherapy using verapamil and nifedipine on left ventricular anatomy, systolic performance, and adrenergic tone.

January 1, 1988Journal of Cardiovascular Pharmacology

Reversal of Cardiac Hypertrophy by Long-Term Treatment with Calcium Antagonists in Hypertensive Patients

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Why the study?

Does long-term treatment with verapamil or nifedipine reduce left ventricular mass and preserve systolic function in hypertensive patients?

Population

19 hypertensive patients

Comparison

Verapamil or nifedipine monotherapy for 6 months vs Baseline measurements on placebo

Design

Cohort

Follow-up

6 months

Authors

EAE. Agabiti-RoseiUniversity of Brescia MMMaría Lorenza MuiesanPreventive Cardiology GRGiuseppe RomanelliMount Sinai Hospital

Discussion

Member takes

Implication

Supports CCB use for LVH regression in hypertension; leaves open randomized confirmation of clinical outcomes.

Key Points

To evaluate the effects of long-term antihypertensive monotherapy using verapamil and nifedipine on left ventricular anatomy, systolic performance, and adrenergic tone.
Monotherapy was evaluated in hypertensive patients receiving either verapamil (240 mg/day, n=9) or nifedipine (40 mg/day, n=10) over 6 months following a placebo phase.
Assessed blood pressure, heart rate, plasma catecholamines, β-adrenergic sensitivity to isoproterenol (CD25), and echocardiographic left ventricular mass and function at rest and during a 3-minute handgrip stress test.
Both treatments significantly decreased blood pressure (p < 0.05) and induced significant regression of left ventricular mass at 6 months (p < 0.01 for verapamil, p < 0.05 for nifedipine).
Verapamil did not alter heart rate or plasma catecholamines but increased CD25 (p < 0.05), whereas nifedipine significantly increased heart rate, cardiac output, and plasma catecholamines (p < 0.05) without altering CD25.
Left ventricular systolic performance relative to end-systolic wall stress was maintained within the 95% prediction limits of healthy volunteers both at rest and during stress for both drugs.

Structured PICO

Does long-term treatment with verapamil or nifedipine reduce left ventricular mass and preserve systolic function in hypertensive patients?

Population

19 hypertensive patients

Intervention

Verapamil (240 mg/day, n=9) or nifedipine (40 mg/day, n=10) monotherapy for 6 months

Comparator

Baseline measurements on placebo

Outcome

Left ventricular (LV) anatomy and function (LV mass and systolic function), adrenergic activity, and β-adrenergic sensitivitysurrogate

Long-term monotherapy with verapamil or nifedipine in hypertensive patients significantly reduces left ventricular hypertrophy while preserving systolic function.

Cite This Study

Agabiti-Rosei et al. (1988) studied this question.

synapsesocial.com/papers/6a701e486c240de38cdbae92 https://doi.org/10.1097/00005344-198812006-00019

Topics

Hypertension management

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Reversal of Cardiac Hypertrophy by Long-Term Treatment with Calcium Antagonists in Hypertensive Patients

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Topics

Reversal of Cardiac Hypertrophy by Long-Term Treatment with Calcium Antagonists in Hypertensive Patients

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

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Topics

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