Why the study?
Do different classes of antihypertensive agents (nifedipine, timolol, indapamide) differentially affect left ventricular mass and hemodynamics in patients with hypertension?
Population
26 patients with hypertension and left ventricular hypertrophy
Comparison
Nifedipine, timolol, or indapamide vs Active comparators
Design
Cohort
Authors
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Supports LV mass reduction across antihypertensive classes; leaves open whether class-specific hemodynamic effects alter outcomes.
Do different classes of antihypertensive agents (nifedipine, timolol, indapamide) differentially affect left ventricular mass and hemodynamics in patients with hypertension?
Reduction of left ventricular mass in hypertension is achievable with multiple classes of antihypertensive agents and does not appear to be solely dependent on sympathetic nervous system modulation.
Mace et al. (1985) studied this question.
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