Key result
Both nifedipine and captopril induced a significant reduction in end-diastolic posterior wall and septum thickness and an increase in end-diastolic volume.
Why the study?
Does antihypertensive therapy with nifedipine or captopril reduce left ventricular mass and volume in patients with essential hypertension?
Population
16 patients with essential hypertension
Comparison
Nifedipine (n=8) or Captopril (n=8) for 6 months vs Active comparator and pre-treatment baseline
Design
Cohort
Follow-up
6 months
Authors
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May support LV geometry changes with these agents in hypertension; hypothesis-generating for mechanisms beyond true hypertrophy regression.
Does antihypertensive therapy with nifedipine or captopril reduce left ventricular mass and volume in patients with essential hypertension?
Nifedipine and captopril reduce LV wall thickness and improve diastolic function in essential hypertension, likely due to reduced wall tension rather than true regression of hypertrophy.
Sheiban et al. (1987) studied essential hypertension (n=16). Nifedipine vs. Captopril was evaluated on left ventricular (LV) mass and volume. Both nifedipine and captopril induced a significant reduction in end-diastolic posterior wall and septum thickness and an increase in end-diastolic volume.
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