Why the study?
Does captopril alone or combined with chlorthalidone reduce left ventricular mass and improve function in uncomplicated hypertensive patients?
Population
20 hypertensive patients without clinical or electrocardiographic signs of cardiac involvement
Comparison
Sequential treatment: captopril for 8 weeks… vs Baseline (placebo for two weeks)
Design
Cohort
Follow-up
16 weeks of active treatment
Authors
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May support LVH regression with captopril in hypertension; hypothesis-generating and requires RCT confirmation before practice change.
Does captopril alone or combined with chlorthalidone reduce left ventricular mass and improve function in uncomplicated hypertensive patients?
Captopril, alone or with chlorthalidone, effectively reverses left ventricular hypertrophy in uncomplicated hypertensive patients.
Lombardo et al. (1983) studied this question.
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