Key result
Nitrendipine matches captopril in reducing circadian blood pressure and regressing left ventricular mass.
Why the study?
No study had allowed a true comparison of nitrendipine and captopril regarding their effects on circadian blood pressure and left ventricular hypertrophy regression in hypertensive patients.
Does nitrendipine compared to captopril improve circadian blood pressure and left ventricular hypertrophy in patients with newly diagnosed arterial hypertension?
Population
86 patients with newly diagnosed arterial hypertension and echocardiographic left ventricular hypertrophy
Comparison
Nitrendipine vs captopril
Design
Randomized treatment trial
Follow-up
38 weeks
Authors
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Does not support preferring either agent for LV mass reduction; leaves open whether effects alter clinical outcomes in RCTs.
RCT (n=86)
randomized
Does nitrendipine compared to captopril improve circadian blood pressure and left ventricular hypertrophy in patients with newly diagnosed arterial hypertension?
Absolute Event Rate: 15% vs 21%
p-value: p=<0.001
Long-term therapy with captopril and nitrendipine leads to a comparable degree of circadian blood pressure reduction and regression of hypertensive left ventricular hypertrophy.
Machnig et al. (2008) conducted an RCT in Essential hypertension with left ventricular hypertrophy (n=86). Nitrendipine vs. Captopril was evaluated on Mean percentage decrease in left ventricular muscle mass (p=<0.001). Nitrendipine and captopril led to a comparable degree of circadian blood pressure reduction and mean percentage decrease in left ventricular muscle mass (15% vs 21%).
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