Why the study?
Does nitrendipine reduce blood pressure and left ventricular mass compared to captopril in hypertensive type 2 diabetic patients with LVH?
Population
75 patients with stable type 2 diabetes and mild-to-moderate hypertension with left ventricular hypertrophy
Comparison
Nitrendipine for 36 weeks vs Captopril for 36 weeks
Design
RCT, random allocation
Follow-up
36 weeks
Authors
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Nitrendipine matches captopril for BP control and LVH reversal in diabetic hypertensives; confirms CCBs as viable alternative to ACEIs.
Does nitrendipine reduce blood pressure and left ventricular mass compared to captopril in hypertensive type 2 diabetic patients with LVH?
Nitrendipine is as effective as captopril in reducing blood pressure and reversing left ventricular hypertrophy in hypertensive type 2 diabetic patients, without adverse metabolic effects.
Scognamiglio et al. (1997) studied this question.
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