December 1, 1986Clinical Pharmacology & Therapeutics
Effect of the calcium channel blocker nitrendipine on left ventricular mass in patients with hypertension
Why the study?
Does nitrendipine reduce echocardiographic left ventricular mass in patients with mild hypertension?
Population
58 patients with mild hypertension
Design
Cohort
Follow-up
12 months
Authors
Discussion
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Implication
Nitrendipine lowers BP without significant LV mass change in mild hypertension; hypothesis-generating for differential CCB effects on regression.
Structured PICO
Does nitrendipine reduce echocardiographic left ventricular mass in patients with mild hypertension?
P
Population
58 patients with mild hypertension
I
Intervention
Nitrendipine as monotherapy or in combination with propranolol or a diuretic for 12 months
O
Outcome
Echocardiographic left ventricular (LV) masssurrogate
Nitrendipine effectively lowers blood pressure but does not significantly reduce left ventricular mass in patients with mild hypertension over 12 months.
Cite This Study
Drayer et al. (1986) studied this question.