Static platelet adhesion, flow cytometry and serum TXB2 levels for monitoring platelet inhibiting treatment with ASA and clopidogrel in coronary artery disease: a randomised cross-over study
Why the study?
Can a static platelet adhesion assay detect the platelet inhibiting effects of ASA and clopidogrel in patients with recent acute coronary syndrome?
Population
29 patients with a recent acute coronary syndrome and 29 matched healthy controls
Comparison
Acetylsalicylic acid combined with clopidogrel… vs Cross-over comparison between ASA alone…
Design
RCT, randomised cross-over design
Authors
Discussion
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Implication
Static platelet adhesion assay detects clopidogrel effects in recent ACS; extends pharmacodynamic monitoring options alongside flow cytometry.
Structured PICO
Can a static platelet adhesion assay detect the platelet inhibiting effects of ASA and clopidogrel in patients with recent acute coronary syndrome?
P
Population
29 patients with a recent acute coronary syndrome and 29 matched healthy controls
I
Intervention
Acetylsalicylic acid (ASA) combined with clopidogrel, or monotherapy with either drug alone
C
Comparator
Cross-over comparison between ASA alone, clopidogrel alone, and combination therapy
O
Outcome
Platelet function measured by flow cytometry, serum thromboxane B2 (TXB2)-levels, and static platelet adhesion to different protein surfacessurrogate
Indirect pharmacodynamic measures of ASA and clopidogrel effects, such as static platelet adhesion, can be used alongside ADP-induced activation and serum TXB2 to evaluate anti-platelet treatment.
Cite This Study
Eriksson et al. (2009) studied this question.