Why the study?
Endotracheal intubation causes noxious hemodynamic stimulation, prompting the search for an ideal premedicant agent to attenuate this response.
Does oral clonidine premedication attenuate hemodynamic responses to laryngoscopy and intubation in patients undergoing elective surgery?
Population
44 patients aged 18-65 years, ASA I-II undergoing elective surgery under general anesthesia
Comparison
Oral clonidine (100 mcg) vs placebo (vitamin B complex)
Design
Randomized observational comparative study
Follow-up
30 min
Authors
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Oral clonidine may attenuate intubation hemodynamics; leaves open confirmation in randomized trials.
Does oral clonidine premedication attenuate hemodynamic responses to laryngoscopy and intubation in patients undergoing elective surgery?
Oral clonidine 100 mcg given 60-90 minutes before induction effectively attenuates the hemodynamic stress response to laryngoscopy and intubation.
Kishnani et al. (2022) studied this question.
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