Why the study?
Does oral clonidine reduce the hemodynamic stress response during laryngoscopy, intubation, and operative procedures in adults undergoing elective surgery under general anesthesia?
Does oral clonidine reduce the hemodynamic stress response during laryngoscopy, intubation, and operative procedures in adults undergoing elective surgery under general anesthesia?
Oral clonidine premedication at 4 mcg/kg effectively attenuates the hemodynamic stress response associated with laryngoscopy and intubation.
Endotracheal intubation constitutes a period of extreme hemodynamic stress. Clonidine, α2 adrenergic agonist, slows down the heart rate and leads to a dose‑dependent decrease in systolic and diastolic blood pressure. It has 100% bioavailability following oral administration.
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Jehangir Allam (2018) studied this question.
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