Why the study?
Does the presence of ACE gene polymorphisms (DD and ID genotypes) increase the risk of developing coronary artery disease in an Eastern Indian population?
Does the presence of ACE gene polymorphisms (DD and ID genotypes) increase the risk of developing coronary artery disease in an Eastern Indian population?
The DD and ID genotypes of the ACE gene are significantly associated with an increased risk of coronary artery disease in the Eastern Indian population, with risk further modified by diabetes, hypertension, and tobacco use.
ACE DD/ID genotypes were associated with CAD in Eastern Indians; leaves open prospective validation before any risk-stratification role.
AIM: A case control study was designed to assess whether the prevalence of ACE gene polymorphism has any role in the development of CAD. METHODS: The study included unrelated 217 cases with CAD and 255 healthy controls. PCR was done using primers followed by agarose gel electrophoresis for study of different ACE gene polymorphisms. Multiple logistic regression analysis was carried out to find association between studied genotypes and lifestyle as well as biochemical risk factors. RESULTS: Both DD [OR: 2.16; 95%CI: (60.60-67.40)] and ID [OR: 1.48; 95%CI: (93.28-97.72)] genotypes of the ACE gene showed significant associations in the development of CAD. Coexistence of diabetes and hypertension found to be risk modifier of the disease. Tobacco intake in various forms elevates the risk of the disease among the cases with risk genotypes. CONCLUSION: ID and DD genotypes of ACE gene came out to be predisposing factors for the CAD cases in our study population.
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Dhar et al. (2012) studied this question.
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