Why the study?
Does co-treatment with valsartan and bosentan reduce renal fibrosis in a unilateral ureteral obstruction mouse model?
Does co-treatment with valsartan and bosentan reduce renal fibrosis in a unilateral ureteral obstruction mouse model?
Co-inhibition of Angiotensin II Receptor and Endothelin-1 provides additive protective effects against renal fibrosis in a mouse model of unilateral ureteral obstruction.
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Additive antifibrotic effect of dual ET-1/RAS blockade in murine UUO; hypothesis-generating for clinical translation in obstructive nephropathy.
Chang et al. (2016) studied this question.
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